Link to K03D10.1RNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
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RNAi Experiment: JA:K03D10.1 Ace View of JA:K03D10.1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  K03D10.1 (kal-1)
Description of "K03D10.1"  kal-1 encodes a cell surface protein that contains a WAP-type protease inhibitor domain and Type III fibronectin domains and is the C. elegans ortholog of human KAL-1, mutated in the X-linked form of the neurological disorder Kallmann syndrome; in C. elegans, both kal-1 loss-of-function mutations and kal-1 overexpression result in similar phenotypes that indicate KAL-1 activity is required for epithelial morphogenesis and axon branching; kal-1 transcriptional reporters reveal expression beginning in the 50-cell stage embryo in 2-3 cells with later embryonic expression in at least 8-10 AB-derived ventral neuroblasts that are a substrate for migrating epidermal cells during ventral enclosure; later expression in larvae and adults is restricted to anterior neurons, including AIY, AIZ, RID, M5, ASI, and labial sensory neurons, ventral nerve cord motorneurons, midbody neurons HSN, CAN, and PVM, tail neurons DVB, DVC, and PDB, and the nonneuronal excretory cell as well as in uterine muscles; in the AIY interneurons, kal-1 is part of a gene battery whose expression is under the control of the CEH-10 and TTX-3 Paired and LIM-type homeodomains, respectively.
KOG Annotation  Adhesion-type protein
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:14129949..14131026)
Transcript overlap: 921 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 882
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "K03D10.1" Links  Wormbase NCBI
JA:K03D10.1 Phenotypes Help with Phenotypes
Phenotype  WT
JA:K03D10.1 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_K03D10.1 (PCR_reagent)
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Date  2000-11-16
Gene Plot of K03D10.1 Browse using GBrowse
Gene Graph