RNAi Card Page

RNAi Experiment: JA:K05F1.7

Genes Inhibited

Gene Inhibited

Description of "K05F1.7"

msp-63 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

ePCR	Status: Unique_ePCR (II:5796600..5797666) Transcript overlap: 384 nt
Sliding Window	Raw score: 342 Relative score: 1 (This gene has the best score for this RNAi reagent) Specificity index: 0.409
Wormbase (BLAST)	RNAi primary

External "K05F1.7" Links

Gene Inhibited

K05F1.2 (msp-142)

Description of "K05F1.2"

msp-142 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 155 Relative score: 0.453 (Best raw score= for Gene ) Specificity index: 0.185
Wormbase (BLAST)	RNAi secondary

External "K05F1.2" Links

Gene Inhibited

ZK1248.4

Description of "ZK1248.4"

Associated GO Term : structural molecule activity

Evidence for Inhibition

Sliding Window	Raw score: 90 Relative score: 0.263 (Best raw score= for Gene ) Specificity index: 0.108
Wormbase (BLAST)	RNAi secondary

External "ZK1248.4" Links

Gene Inhibited

ZK1248.6 (msp-64)

Description of "ZK1248.6"

msp-64 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition