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RNAi Experiment: JA:K08B4.1 Ace View of JA:K08B4.1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  K08B4.1 (lag-1)
Description of "K08B4.1"  lag-1 encodes a transcription factor orthologous to members of the CSL (CBF1, Suppressor of Hairless, LAG-1) family that is highly conserved amongst metazoans; during development, LAG-1 functions as a downstream effector in both the lin-12- and glp-1-mediated Notch-like signaling pathways and accordingly, is required for such processes as germline induction, AC/VU lateral signaling, and embryonic development; LAG-1 can bind a consensus CSL family binding site found in multiple copies in the predicted regulatory regions of lin-12, glp-1, and lag-1, thus implicating LAG-1 as an important component of the positive feedback loop observed in the LIN-12/GLP-1 signaling pathway; LAG-1 is detected in all nuclei of the germ line except mature sperm, somatic gonad, and early embryo.
KOG Annotation  Recombination signal binding protein-J kappa(CBF1, Su(H), HS2NF5)
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (IV:6108105..6109302)
Transcript overlap: 706 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 643
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "K08B4.1" Links  Wormbase NCBI
JA:K08B4.1 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 100 %
Larval  Lvl
Phenotype  Bli
JA:K08B4.1 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_K08B4.1 (PCR_reagent)
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Date  2003-1-10
Gene Plot of K08B4.1 Browse using GBrowse
Gene Graph