Ace View of JA:K08B4.1 | |||
Gene Inhibited | K08B4.1 (lag-1) | ||
Description of "K08B4.1" | lag-1 encodes a transcription factor orthologous to members of the CSL (CBF1, Suppressor of Hairless, LAG-1) family that is highly conserved amongst metazoans; during development, LAG-1 functions as a downstream effector in both the lin-12- and glp-1-mediated Notch-like signaling pathways and accordingly, is required for such processes as germline induction, AC/VU lateral signaling, and embryonic development; LAG-1 can bind a consensus CSL family binding site found in multiple copies in the predicted regulatory regions of lin-12, glp-1, and lag-1, thus implicating LAG-1 as an important component of the positive feedback loop observed in the LIN-12/GLP-1 signaling pathway; LAG-1 is detected in all nuclei of the germ line except mature sperm, somatic gonad, and early embryo. | ||
KOG Annotation  | Recombination signal binding protein-J kappa(CBF1, Su(H), HS2NF5) |
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Evidence for Inhibition | |||
External "K08B4.1" Links | |||
Embryonic | Emb Penetrance 100 % | ||
Larval | Lvl Mlt |
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Phenotype | Bli |
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Laboratory | JA | ||
RNAi Reagent & Type | sjj_K08B4.1 (PCR_reagent) | ||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||
Date | 2003-1-10 | ||
Gene Plot of K08B4.1 | |||