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RNAi Experiment: JA:K10B2.1 Ace View of JA:K10B2.1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  K10B2.1 (lin-23)
Description of "K10B2.1"  lin-23 encodes an F-box- and WD-repeat-containing protein that is orthologous to Saccharomyces cerevisiae MET30 and human beta TRCP (OMIM:603482), both components of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; LIN-23 negatively regulates postembryonic cell divsions in all tissue types, and specifically, has been shown to function cell autonomously in the vulva to negatively regulate cell cycle progression and allow for cell cycle exit; LIN-23 is most highly expressed in the early embryo and adult germline.
KOG Annotation  Beta-TrCP (transducin repeats containing)/Slimb proteins
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:6371945..6373071)
Transcript overlap: 945 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 882
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "K10B2.1" Links  Wormbase NCBI
JA:K10B2.1 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 40 %
Larval  Gro
Lvl
Adult  Lon
Unc
JA:K10B2.1 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_K10B2.1 (PCR_reagent)
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Date  2003-1-10
Gene Plot of K10B2.1 Browse using GBrowse
Gene Graph