Ace View of JA:R06C7.8 | |||
Gene Inhibited | R06C7.8 (bub-1) | ||
Description of "R06C7.8" | bub-1 encodes a serine/threonine kinase orthologous to Saccharomyces cerevisiae BUB1 which is required for proper function of the mitotic spindle assembly checkpoint and human BUB1 (OMIM:602452) which is mutated in some colorectal cancers; BUB-1 activity is required at several stages of development, including embryogenesis; BUB-1 is expressed predominantly in the anterior of the embryo and in hypodermal seam cells during the L1 and L2 larval stages. | ||
KOG Annotation  | Mitotic checkpoint serine/threonine protein kinase |
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Evidence for Inhibition | |||
External "R06C7.8" Links | |||
Embryonic | Emb Penetrance 100 % | ||
Larval | Lvl |
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Adult | Pvl Rup |
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Phenotype | Mul
Differentiated, not enclosed |
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Movies/Stacks/Images | |||
Laboratory | JA | ||
RNAi Reagent & Type | sjj_R06C7.8 (PCR_reagent) | ||
Reference | Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...." | ||
Date | 2000-11-16 | ||
Gene Plot of R06C7.8 | |||