RNAi Experiment: JA:R13H8.2 |
Ace View of JA:R13H8.2
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Genes Inhibited |
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Gene Inhibited |
R13H8.1 (daf-16) |
Description of "R13H8.1" |
daf-16 encodes a transcription factor of the HNF-3/forkhead family (orthologous to mammalian AFX, FKHR, and FKHRL1) that acts in an insulin-mediated pathway to affect dauer formation, and that also affects life span and reproduction; DAF-16 can interact with CBP-1 in vitro, and interacts genetically both with other genes in the insulin signaling and with the nuclear hormone receptor DAF-12; daf-16 is broadly expressed in most if not all cells (though expression in the pharynx and in the somatic gonad differ for the two isoforms); DAF-16 is homologous to human FORKHEAD BOX O1A (FOXO1A), which when mutated leads to rhabdomyosarcoma (OMIM:136533). |
Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (I:10762888..10765350)
Transcript overlap: 784 nt |
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Sliding Window |
Raw score: 616
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "R13H8.1" Links |
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JA:R13H8.2 Phenotypes |
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Phenotype |
WT
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JA:R13H8.2 Experiment Details |
Ace View |
Laboratory |
JA |
RNAi Reagent & Type |
sjj_R13H8.2 (PCR_reagent) |
Reference |
Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...." |
Date |
2000-11-16 |
Gene Plot of R13H8.1 |
Browse using GBrowse
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