| RNAi Experiment: JA:T04A8.14 |
Ace View of JA:T04A8.14
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| Genes Inhibited |
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| Gene Inhibited |
T04A8.14 (emb-5) |
| Description of "T04A8.14" |
emb-5 encodes the C. elegans ortholog of the Spt6 family of RNA polymerase II transcription elongation factors; first identified in screens for temperature-sensitive embryonic lethal mutations, emb-5 is required for the correct timing of the second E (endoderm)-cell division in the early embryo and thus, for normal embryonic gastrulation; in addition, emb-5 activity is required postembryonically for proper gonad development; in yeast two-hybrid studies, EMB-5 interacts with the intracellular domains of LIN-12 and GLP-1, suggesting that EMB-5 functions as a positive downstream effector in Notch-like signaling pathways during C. elegans development; emb-5 mRNA is most abundant during embryonic stages, with lower levels apparent during the L1-L3 larval stages, and even lower levels observed during L4. |
| KOG Annotation |
Transcription elongation factor SPT6
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| Evidence for Inhibition |
| ePCR |
Status: Unique_ePCR (III:4718464..4719651)
Transcript overlap: 1091 nt |
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| Sliding Window |
Raw score: 1028
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
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| External "T04A8.14" Links |
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| JA:T04A8.14 Phenotypes |
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| Embryonic |
Emb Penetrance 80 % |
| Adult |
Sck
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| JA:T04A8.14 Experiment Details |
Ace View |
| Laboratory |
JA |
| RNAi Reagent & Type |
sjj_T04A8.14 (PCR_reagent) |
| Reference |
Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
| Date |
2003-1-10 |
| Gene Plot of T04A8.14 |
Browse using GBrowse
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