RNAi Experiment: JA:T20B12.2 |
Ace View of JA:T20B12.2
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Genes Inhibited |
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Gene Inhibited |
T20B12.2 (tbp-1) |
Description of "T20B12.2" |
tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth. |
KOG Annotation  |
TATA-box binding protein (TBP), component of TFIID and TFIIIB
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:7384579..7385681)
Transcript overlap: 794 nt |
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Sliding Window |
Raw score: 731
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "T20B12.2" Links |
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JA:T20B12.2 Phenotypes |
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Embryonic |
Emb Penetrance 80 % |
Larval |
Gro
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JA:T20B12.2 Experiment Details |
Ace View |
Laboratory |
JA |
RNAi Reagent & Type |
sjj_T20B12.2 (PCR_reagent) |
Reference |
Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
Date |
2003-1-10 |
Gene Plot of T20B12.2 |
Browse using GBrowse
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