Ace View of JA:T23D8.4 | |||
Gene Inhibited | T23D8.9 (sys-1) | ||
Description of "T23D8.9" | sys-1 encodes a novel protein that contains three divergent armadillo repeats; during gonadogenesis, SYS-1 functions in a Wnt/MAPK signaling pathway as a dosage-dependent beta-catenin-like transcriptional coactivator required for specification of distal cell fates; consistent with its role as a beta-catenin, SYS-1 interacts, in yeast two-hybrid and coimmunoprecipitation assays, with the POP-1/TCF transcription factor with which it can stimulate transcription via TCF binding sites; in two hybrid-assays, the POP-1/SYS-1 interaction requires the N-terminal beta-catenin binding domain of POP-1, and most of the SYS-1 protein; the SYS-1 expression pattern is not yet known. | ||
Evidence for Inhibition | |||
External "T23D8.9" Links | ![]() ![]() |
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Embryonic | Emb Penetrance 100 % Led (Differentiated, not enclosed) | ||
Adult | Bmd Pvl |
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Movies/Stacks/Images | ![]() ![]() ![]() ![]() |
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Laboratory | JA | ||
RNAi Reagent & Type | sjj_T23D8.4 (PCR_reagent) | ||
Reference | Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...." | ||
Date | 2000-11-16 | ||
Gene Plot of T23D8.9 | |||
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