RNAi Card Page

RNAi Experiment: JA:T27E4.2

Genes Inhibited

Gene Inhibited

Description of "T27E4.2"

hsp-16.11 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.1; hsp-16.11 expression is induced in response to heat shock or other environmental stresses; HSP-16.11 is likely to function as passive ligand temporarily preventing unfolded proteins from aggregating; HSP-16.11 has been shown to interact with intracellular human beta amyloid peptide, a primary component of the extracellular plaques found in Alzheimer's disease.

Evidence for Inhibition

ePCR	Status: Unique_ePCR (V:9092559..9093725) Transcript overlap: 438 nt
Sliding Window	Raw score: 396 Relative score: 1 (This gene has the best score for this RNAi reagent) Specificity index: 0.5
Wormbase (BLAST)	RNAi primary

External "T27E4.2" Links

Gene Inhibited

T27E4.8 (hsp-16.1)

Description of "T27E4.8"

hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating.

KOG Annotation

Alpha crystallins