RNAi Experiment: JA:W02B9.1 |
Ace View of JA:W02B9.1
|
Genes Inhibited |
|
Gene Inhibited |
W02B9.1 (hmr-1) |
Description of "W02B9.1" |
hmr-1 encodes two isoforms of a classical cadherin that contain extracellular cadherin, EGF-like, and laminin G domains as well as a highly conserved intracellular domain that binds beta-catenin; by homology, the HMR-1 proteins are predicted to function as calcium-dependent, homophilic cell-cell adhesion receptors; in vivo, HMR-1A activity is required for mediating the cell migrations, cell shape changes, and presumably actin cytoskeleton rearrangements that occur during embryonic morphogenesis; HMR-1B is required for fasciculation and outgrowth of a subset of motor neuron processes; HMR-1 antibodies detect expression in all embryonic blastomeres at early stages of development but as hypodermal adherens junctions form and morphogenesis begins, HMR-1 becomes highly expressed in the apical junctions of all hypodermal cells; later, HMR-1 is expressed primarily at the apical margins of hypodermal, pharyngeal, and intestinal cells in a pattern consistent with localization to adherens junctions; an HMR-1B reporter fusion is expressed in neurons, including the DD, VD, and AS class of motor neurons; HMR-1 activity is required for proper localization of other junctional components, such as HMP-1/alpha-catenin and HMP-2/beta-catenin, but not for localization of AJM-1, the junctional component recognized by the MH27 antibody. |
KOG Annotation  |
Cadherin repeats
|
|
Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (I:11078962..11080597)
Transcript overlap: 892 nt |
|
Sliding Window |
Raw score: 850
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.456 |
Wormbase (BLAST) |
RNAi primary |
|
External "W02B9.1" Links |
|
Gene Inhibited |
E03H4.8 |
Description of "E03H4.8" |
Associated GO Term : protein transporter activity |
KOG Annotation  |
Vesicle coat complex COPI, beta' subunit
|
|
Evidence for Inhibition |
Sliding Window |
Raw score: 383
Relative score: 0.451 (Best raw score= for Gene )
Specificity index: 0.205 |
|
External "E03H4.8" Links |
|
Gene Inhibited |
M142.7 |
Evidence for Inhibition |
Sliding Window |
Raw score: 67
Relative score: 0.079 (Best raw score= for Gene )
Specificity index: 0.036 |
|
External "M142.7" Links |
|
Gene Inhibited |
W05B2.3 |
Evidence for Inhibition |
Sliding Window |
Raw score: 95
Relative score: 0.112 (Best raw score= for Gene )
Specificity index: 0.051 |
|
External "W05B2.3" Links |
|
Gene Inhibited |
T07C12.5 (srj-34) |
Evidence for Inhibition |
Sliding Window |
Raw score: 339
Relative score: 0.399 (Best raw score= for Gene )
Specificity index: 0.182 |
|
External "T07C12.5" Links |
|
Gene Inhibited |
R05D8.12 (srx-27) |
Evidence for Inhibition |
Sliding Window |
Raw score: 131
Relative score: 0.154 (Best raw score= for Gene )
Specificity index: 0.07 |
|
External "R05D8.12" Links |
|
JA:W02B9.1 Phenotypes |
|
|
Embryonic |
Emb Penetrance 10 % |
Adult |
Bmd Dpy Unc
|
JA:W02B9.1 Experiment Details |
Ace View |
Laboratory |
JA |
RNAi Reagent & Type |
sjj_W02B9.1 (PCR_reagent) |
Reference |
Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...." |
Date |
2000-11-16 |
Gene Plot of W02B9.1 |
Browse using GBrowse
|
|
Gene Plot of M142.7 |
Browse using GBrowse
|
|
Gene Plot of E03H4.8 |
Browse using GBrowse
|
|
Gene Plot of W05B2.3 |
Browse using GBrowse
|
|
Gene Plot of T07C12.5 |
Browse using GBrowse
|
|
Gene Plot of R05D8.12 |
Browse using GBrowse
|
|