| Description of "W07B3.2" |
gei-4 encodes a protein with a coiled-coil domain (predicted to mediate protein-protein interactions), an internal repeat of 69 residues (covering residues 134-202, 203-265, and 266-328 of W07B3.2a), and a glutamine/asparagine-rich domain; GEI-4 is paralogous to Y50D7A.8 and Y59C2A.3, physically interacts with GEX-2, and is required for embryonic viability, fertility, and vulval morphogenesis; GEI-4 is claimed to have weak homology to trichohyalin, a mammalian intermediate filament interacting protein; the similarity of the mutant phenotypes of gei-4, gex-2 and gex-3 and their interaction sugggest that the GEX-2/GEX-3/GEI-4 protein complex is essential for the regulation of intermediate filaments during rearrangement of the cytoskeleton that occurs in embryogenesis; GFI-2, an ankyrin-repeat protein associates with GEI-4 and exhibits a similar mutant phenotype, suggesting that gfi-2 is also involved in intermediate filament dynamics. |
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