RNAi Experiment: JA:Y54G11A.10 |
Ace View of JA:Y54G11A.10
|
Genes Inhibited |
|
Gene Inhibited |
Y54G11A.10 (lin-7) |
Description of "Y54G11A.10" |
lin-7 encodes a protein that contains a PDZ domain and an L27 domain, two protein interaction domains that likely serve as organizational centers for large macromolecular complexes in polarized cells; LIN-7 is required for proper basolateral localization of the LET-23/EGF receptor in vulval epithelial cells, and along with LIN-2 and LIN-10, forms a protein complex that likely mediates this asymmetric localization with LIN-7 simultaneously binding to the C-terminus of LET-23 and an internal region of LIN-2; a LIN-7 translational reporter fusion indicates that LIN-7 is expressed at intestinal cell junctions; expression in vulval epithelial cells is detected only upon overexpression via heat shock, and reveals localization primarily at the lateral cell junctions of the vulval precursor cells P5.p and P6.p |
KOG Annotation  |
Receptor targeting protein Lin-7
|
|
Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (II:14347207..14349281)
Transcript overlap: 781 nt |
|
Sliding Window |
Raw score: 655
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
|
External "Y54G11A.10" Links |
|
JA:Y54G11A.10 Phenotypes |
|
|
Larval |
Gro
|
Adult |
Clr
|
JA:Y54G11A.10 Experiment Details |
Ace View |
Laboratory |
JA |
RNAi Reagent & Type |
sjj_Y54G11A.10 (PCR_reagent) |
Reference |
Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
Date |
2003-1-10 |
Gene Plot of Y54G11A.10 |
Browse using GBrowse
|
|