RNAi Experiment: JA:Y55D5A_391.b |
Ace View of JA:Y55D5A_391.b
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Genes Inhibited |
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Gene Inhibited |
Y55D5A.5 (daf-2) |
Description of "Y55D5A.5" |
daf-2 encodes a predicted receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage, adult longevity, reproduction, fat storage, and response to exogenous stressors such as high temperature or bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary signals that coordinate growth and longevity throughout the animal. |
KOG Annotation  |
Insulin/growth factor receptor (contains protein kinase domain)
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:3012401..3014686)
Transcript overlap: 1277 nt |
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Sliding Window |
Raw score: 1214
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.829 |
Wormbase (BLAST) |
RNAi primary |
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External "Y55D5A.5" Links |
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Gene Inhibited |
F58E2.10 (srz-22) |
Evidence for Inhibition |
Sliding Window |
Raw score: 251
Relative score: 0.207 (Best raw score= for Gene )
Specificity index: 0.171 |
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External "F58E2.10" Links |
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JA:Y55D5A_391.b Phenotypes |
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Phenotype |
WT
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JA:Y55D5A_391.b Experiment Details |
Ace View |
Laboratory |
JA |
RNAi Reagent & Type |
sjj_Y55D5A_391.b (PCR_reagent) |
Reference |
Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
Date |
2003-1-10 |
Gene Plot of F58E2.10 |
Browse using GBrowse
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Gene Plot of Y55D5A.5 |
Browse using GBrowse
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