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RNAi Experiment: JA:Y55D5A_391.b Ace View of JA:Y55D5A_391.b
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  Y55D5A.5 (daf-2)
Description of "Y55D5A.5"  daf-2 encodes a predicted receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage, adult longevity, reproduction, fat storage, and response to exogenous stressors such as high temperature or bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary signals that coordinate growth and longevity throughout the animal.
KOG Annotation  Insulin/growth factor receptor (contains protein kinase domain)
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:3012401..3014686)
Transcript overlap: 1277 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 1214
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.829
Wormbase (BLAST) RNAi primary
External "Y55D5A.5" Links  Wormbase NCBI
Gene Inhibited  F58E2.10 (srz-22)
Evidence for Inhibition 
Sliding Window Raw score: 251
Relative score: 0.207 (Best raw score= for Gene )
Specificity index: 0.171
External "F58E2.10" Links  Wormbase NCBI
JA:Y55D5A_391.b Phenotypes Help with Phenotypes
Phenotype  WT
JA:Y55D5A_391.b Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_Y55D5A_391.b (PCR_reagent)
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Date  2003-1-10
Gene Plot of F58E2.10 Browse using GBrowse
Gene Graph
Gene Plot of Y55D5A.5 Browse using GBrowse
Gene Graph