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RNAi Experiment: JA:Y73C8B.b Ace View of JA:Y73C8B.b
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  Y73C8B.4 (lag-2)
Description of "Y73C8B.4"  lag-2 encodes a transmembrane protein of the Delta/Serrate/Lag-2 (DSL) family that functions as a signaling ligand for the GLP-1 and LIN-12 Notch-like receptors; LAG-2 is required for larval viability and for cell fate decisions involving the germline (meiosis vs mitosis), the somatic gonad, and the early embryo; in addition, LAG-2 functions redundantly with the transmembrane APX-1 and secreted DSL-1 ligands to regulate lateral signaling during vulval development; LAG-2 is expressed in the distal tip cell of the somatic gonad, the ventral nerve cord, the descendants of ABalap and MSap in the developing embryo, and in all six vulval precursor cells (VPCs) during the early L3 stage, with later expression in the VPCs generally restricted to P6.p; lag-2 expression in the vulval cells is regulated by the LET-23/EGF receptor signaling pathway and the SUR-2 component of the Mediator transcription complex.
KOG Annotation  Proteins containing Ca2+-binding EGF-like domains
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (V:3188129..3189306)
Transcript overlap: 847 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 763
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "Y73C8B.4" Links  Wormbase NCBI
JA:Y73C8B.b Phenotypes Help with Phenotypes
Phenotype  WT
JA:Y73C8B.b Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_Y73C8B.b (PCR_reagent)
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Date  2003-1-10
Gene Plot of Y73C8B.4 Browse using GBrowse
Gene Graph