Link to ZK770.3.1Link to ZK770.3.2RNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
RNAi Experiment: JA:ZK770.3 Ace View of JA:ZK770.3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  ZK770.3 (inx-12)
Description of "ZK770.3"  inx-12 (innexin=invertebrate connexin analogue) encodes a protein of the innexin family; innexins are gap junction proteins similar in function, though dissimilar in sequence to the vertebrate connexins; innexins are the only known gap junction proteins in invertebrates; inx-12 and inx-13 appear to be a tandom duplication; RNA interference of inx-12 results in an arrest at the L1 larval stage with fluid filled dead rods; this phenotype and sequence homology to Drosophila innexins suggest that INX-12 may be required to form gap junctions between the excretory canal and hypodermis, thus playing an essential role in osmoregulation; an INX-12::GFP fusion protein is expressed in the excretory canal.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:3755369..3757487)
Transcript overlap: 905 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 822
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "ZK770.3" Links  Wormbase NCBI
JA:ZK770.3 Phenotypes Help with Phenotypes
Phenotype  WT
JA:ZK770.3 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  sjj_ZK770.3 (PCR_reagent)
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Date  2000-11-16
Gene Plot of ZK770.3 Browse using GBrowse
Gene Graph