Link to ZK1151.1bLink to ZK1151.1cLink to Y47H9B.2Link to ZK1151.1gLink to ZK1151.1eLink to ZK1151.1aLink to ZK1151.1dLink to ZK1151.1fLink to F53B8.1RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentLink to Y73B6BL.7Link to M116.5geneMap
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RNAi Experiment: JN:yk529f3 Ace View of JN:yk529f3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  ZK1151.1 (vab-10)
Description of "ZK1151.1"  vab-10 encodes, by alternative splicing, two spectraplakins (VAB-10A and VAB-10B) that are jointly required for mechanical resilience of the epidermis under strain by the contraction of actin microfilaments mechanically linked to fibrous organelles (FOs); VAB-10A/B are, accordingly, required for elongation during embryonic morphogenesis; VAB-10A has C-terminal plectin repeats while VAB-10B has spectrin repeats; VAB-10A is required to keep the epidermis and extracellular matrix attached via FOs, while VAB-10B is required to keep the apical and basal epidermal plasma membranes connected during morphogenesis; vab-10a and vab-10b mutations complement one another; vab-10 is orthologous to human BPAG1 (dystonin or MACF2, OMIM:113810, encoding an autoantigen of bullous pemphigoid blistering disease) and dJ562N20.1 (MACF1), and to Drosophila SHORT STOP.
KOG Annotation  Dystonin, GAS (Growth-arrest-specific protein), and related proteins
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 2524
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "ZK1151.1" Links  Wormbase NCBI
JN:yk529f3 Phenotypes Help with Phenotypes
Larval  Let
JN:yk529f3 Experiment Details Ace View
Laboratory  JN
RNAi Reagent & Type  yk529f3 (cDNA_reagent)
Strain  [cgc4769]peIs1
Remark  co-injectin of gfp dsRNA as a control
Reference  Hanazawa M et al. (2001) Proceedings of the National Academy of Sciences USA "Use of cDNA subtraction and RNA interference screens in combination reveals ...."
Delivery Method  Injection
Date  2001-7-17
Gene Plot of ZK1151.1 Browse using GBrowse
Gene Graph