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RNAi Experiment: KK:SP_12H1 Ace View of KK:SP_12H1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  T20F5.2 (pbs-4)
Description of "T20F5.2"  pbs-4 encodes a B-type subunit of the 26S proteasome's 20S protease core particle; by homology, PBS-4 is predicted to function in ATP/ubiquitin-dependent nonlysosomal protein degradation; loss of pbs-4 activity via RNAi indicates that, in C. elegans, PBS-4 is required for embryonic, germline, and larval development.
KOG Annotation  20S proteasome, regulatory subunit beta type PSMB2/PRE1
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 233
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
External "T20F5.2" Links  Wormbase NCBI
KK:SP_12H1 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 80 - 100 %
Adult  Ste
Egg production ceases in injected animal
Phenotype  Abnormal one-cell shape
Catastrophic one-cell arrest
Movies/Stacks/Images  /static/images/movie.gif /static/images/movie.gif Help
KK:SP_12H1 Experiment Details Ace View
Laboratory  KK
RNAi Reagent & Type  SP12H1 (cDNA_reagent)
Reference  Piano F et al. (2000) Current Biology "RNAi analysis of genes expressed in the ovary of Caenorhabditis ...."
Delivery Method  Injection
Date  2000-12-08
Gene Plot of T20F5.2 Browse using GBrowse
Gene Graph