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RNAi Experiment: KK:SP_3H6 Ace View of KK:SP_3H6
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  T20B12.2 (tbp-1)
Description of "T20B12.2"  tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth.
KOG Annotation  TATA-box binding protein (TBP), component of TFIID and TFIIIB
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 416
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
External "T20B12.2" Links  Wormbase NCBI
KK:SP_3H6 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 80 - 100 %
KK:SP_3H6 Experiment Details Ace View
Laboratory  KK
RNAi Reagent & Type  SP3H6 (cDNA_reagent)
Reference  Piano F et al. (2000) Current Biology "RNAi analysis of genes expressed in the ovary of Caenorhabditis ...."
Delivery Method  Injection
Date  2000-12-08
Gene Plot of T20B12.2 Browse using GBrowse
Gene Graph