RNAi Experiment: KK:SP_3H6 |
Ace View of KK:SP_3H6
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Genes Inhibited |
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Gene Inhibited |
T20B12.2 (tbp-1) |
Description of "T20B12.2" |
tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth. |
KOG Annotation  |
TATA-box binding protein (TBP), component of TFIID and TFIIIB
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Evidence for Inhibition |
Sliding Window |
Raw score: 416
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
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External "T20B12.2" Links |
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KK:SP_3H6 Phenotypes |
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Embryonic |
Emb Penetrance 80 - 100 % |
KK:SP_3H6 Experiment Details |
Ace View |
Laboratory |
KK |
RNAi Reagent & Type |
SP3H6 (cDNA_reagent) |
Reference |
Piano F et al. (2000) Current Biology "RNAi analysis of genes expressed in the ovary of Caenorhabditis ...." |
Delivery Method |
Injection |
Date |
2000-12-08 |
Gene Plot of T20B12.2 |
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