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RNAi Experiment: KK:SP_6H11 Ace View of KK:SP_6H11
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  CD4.6 (pas-6)
Description of "CD4.6"  pas-6 encodes a type 1 alpha subunit of the 26S proteasome's 20S protease core particle (CP); PAS-6 is required for embryonic, larval, and germline development and by homology, is predicted to comprise the outer rings of the proteasome and to play a role in selective degradation of ubiquitinated proteins during development; in vitro, PAS-6 interacts with BRP-1, a glutamine/asparagine (Q/N)-rich domain-containing protein conserved amongst nematodes, and with other members of the proteasome.
KOG Annotation  20S proteasome, regulatory subunit alpha type PSMA1/PRE5
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 692
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
External "CD4.6" Links  Wormbase NCBI
KK:SP_6H11 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 80 - 100 %
Adult  Ste
Egg production ceases in injected animal
Phenotype  Abnormal one-cell shape
Catastrophic one-cell arrest
Movies/Stacks/Images  /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif Help
KK:SP_6H11 Experiment Details Ace View
Laboratory  KK
RNAi Reagent & Type  SP6H11 (cDNA_reagent)
Reference  Piano F et al. (2000) Current Biology "RNAi analysis of genes expressed in the ovary of Caenorhabditis ...."
Delivery Method  Injection
Date  2000-12-08
Gene Plot of CD4.6 Browse using GBrowse
Gene Graph