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RNAi Experiment: KK:SP_7G12 Ace View of KK:SP_7G12
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F53G12.5 (mex-3)
Description of "F53G12.5"  mex-3 encodes two KH domain-containing RNA binding proteins; in the early embryo, maternally provided MEX-3 is required for specifying the identities of the anterior AB blastomere and its descendants, as well as for the identity of the P3 blastomere and proper segregation of the germline P granules; mex-3 mRNA is distributed uniformly in the syncytial core of the adult distal gonad, mature oocytes, and early 1-cell stage embryos, but then becomes more prominent in the AB blastomere and its daughters by the 4-cell stage after which it is rapidly degraded save for the D and P4 blastomeres; MEX-3 protein is also detected uniformly in the cytoplasm of oocytes and 1-cell stage embryos, but like the mRNA, becomes more abundant in AB and its daughters at the 2- and 4-cell stages, respectively, before disappearing; MEX-3 is also detected in association with P granules from the 2-cell stage until the late stages of embryogenesis.
KOG Annotation  Predicted RNA binding protein, contains KH domain
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 808
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
External "F53G12.5" Links  Wormbase NCBI
KK:SP_7G12 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 80 - 100 %
Phenotype  Cytokinesis problems
Movies/Stacks/Images  /static/images/movie.gif /static/images/movie.gif Help
KK:SP_7G12 Experiment Details Ace View
Laboratory  KK
RNAi Reagent & Type  SP7G12 (cDNA_reagent)
Reference  Piano F et al. (2000) Current Biology "RNAi analysis of genes expressed in the ovary of Caenorhabditis ...."
Delivery Method  Injection
Date  2000-12-08
Gene Plot of F53G12.5 Browse using GBrowse
Gene Graph