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RNAi Experiment: KK:SP_8A4 Ace View of KK:SP_8A4
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C47E8.5 (daf-21)
Description of "C47E8.5"  daf-21 encodes a member of the Hsp90 family of molecular chaperones; DAF-21 activity is required for larval development, negative regulation of dauer larva formation, and a number of specific chemosensory behaviors, such as the response to chemicals and odorants detected by the ASE and AWC sensory neurons; a daf-21 sensory defect can be rescued by a cyclic GMP analogue, suggesting that, in regulating chemosensory behaviors, DAF-21 acts at a similar point as the DAF-11 guanylyl cyclase; down-regulation of daf-21 via RNAi results in a small but reproducible reduction in age-1 life span, suggesting that daf-21 is part of a chaperone network required for the extended life span seen in age-1 mutant animals.
KOG Annotation  Molecular chaperone (HSP90 family)
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 364
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
External "C47E8.5" Links  Wormbase NCBI
KK:SP_8A4 Phenotypes Help with Phenotypes
KK:SP_8A4 Experiment Details Ace View
RNAi Reagent & Type  SP8A4 (cDNA_reagent)
Reference  Piano F et al. (2000) Current Biology "RNAi analysis of genes expressed in the ovary of Caenorhabditis ...."
Gene Plot of C47E8.5 Browse using GBrowse
Gene Graph