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RNAi Experiment: KK:SP_8B11 Ace View of KK:SP_8B11
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F13B10.2 (rpl-3)
Description of "F13B10.2"  rpl-3 encodes a large ribosomal subunit L3 protein required in mass RNAi assays for embryonic and larval viability, fertility, and general health; the rpl-3 transcription unit has a nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-3 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-7, rpl-10, rpl-12) have protein products that are involved in translation.
Evidence for Inhibition 
Sliding Window Raw score: 721
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
External "F13B10.2" Links  Wormbase NCBI
KK:SP_8B11 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 80 - 100 %
Adult  Ste
Egg production ceases in injected animal
Phenotype  Catastrophic one-cell arrest
Embryos arrest at different stages
KK:SP_8B11 Experiment Details Ace View
Laboratory  KK
RNAi Reagent & Type  SP8B11 (cDNA_reagent)
Reference  Piano F et al. (2000) Current Biology "RNAi analysis of genes expressed in the ovary of Caenorhabditis ...."
Delivery Method  Injection
Date  2000-12-08
Gene Plot of F13B10.2 Browse using GBrowse
Gene Graph