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RNAi Experiment: MV_SV:mv_AAA03582 Ace View of MV_SV:mv_AAA03582
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  T20B12.2 (tbp-1)
Description of "T20B12.2"  tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth.
KOG Annotation  TATA-box binding protein (TBP), component of TFIID and TFIIIB
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 936
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "T20B12.2" Links  Wormbase NCBI
MV_SV:mv_AAA03582 Phenotypes Help with Phenotypes
Phenotype  Unclassified reduced brood size
MV_SV:mv_AAA03582 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_AAA03582 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of T20B12.2 Browse using GBrowse
Gene Graph