RNAi Experiment: MV_SV:mv_AAA03582 |
Ace View of MV_SV:mv_AAA03582
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Genes Inhibited |
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Gene Inhibited |
T20B12.2 (tbp-1) |
Description of "T20B12.2" |
tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth. |
KOG Annotation  |
TATA-box binding protein (TBP), component of TFIID and TFIIIB
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Evidence for Inhibition |
Sliding Window |
Raw score: 936
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "T20B12.2" Links |
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MV_SV:mv_AAA03582 Phenotypes |
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Phenotype |
Unclassified
reduced brood size
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MV_SV:mv_AAA03582 Experiment Details |
Ace View |
Laboratory |
MV |
RNAi Reagent & Type |
mv_AAA03582 (ORFeome_reagent) |
Remark |
bacterial-feeding RNAi began at the L1 larval stage |
Reference |
Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...." |
Delivery Method |
Bacterial_feeding |
Date |
2004-9-01 |
Gene Plot of T20B12.2 |
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