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RNAi Experiment: MV_SV:mv_AAC14022 Ace View of MV_SV:mv_AAC14022
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  Y48B6A.8 (ace-3)
Description of "Y48B6A.8"  ace-3 encodes one of four C. elegans acetylcholinesterases (AChE); ACE-3 represents ~5% of the total AChE activity in C. elegans and in vitro, hydrolyzes acetylthio-, butyrylthio-, and propionylthiocholine substrates with equal efficiency; although loss-of-function mutations in ace-3 result in no obvious defects, animals doubly mutant with ace-1 or ace-2 have slight defects in backward locomotion and animals triply mutant for ace-1, -2, and -3 arrest as unhatched, yet fully developed, embryos; ace-3 is the downstream gene in an operon with a fourth AChE-encoding gene, ace-4, and transcriptional reporter fusions with ace-4 upstream sequences direct expression in pharyngeal muscles pm3, 4, 5, and 7, the two CAN (canal associated neuron) cells, midbody dorsal body wall muscles in larvae, and several neurons in the head and anal ganglion
KOG Annotation  Acetylcholinesterase/Butyrylcholinesterase
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 1653
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "Y48B6A.8" Links  Wormbase NCBI
MV_SV:mv_AAC14022 Phenotypes Help with Phenotypes
Phenotype  WTRNAi did not cause viable post-embryonic phenotype
MV_SV:mv_AAC14022 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_AAC14022 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of Y48B6A.8 Browse using GBrowse
Gene Graph