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RNAi Experiment: MV_SV:mv_AAC27122 Ace View of MV_SV:mv_AAC27122
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C09G4.4
Evidence for Inhibition 
Sliding Window Raw score: 171
Specificity index: 0.5
Wormbase (BLAST) RNAi primary
External "C09G4.4" Links  Wormbase NCBI
Gene Inhibited  C09G4.5 (mes-6)
Description of "C09G4.5"  mes-6 encodes a WD repeat-containing protein that is orthologous to Drosophila Extra sex combs (Esc); as a member of a Polycomb-like chromatin repressive complex with MES-2 and MES-3, MES-6 is required maternally for normal germline development and during larval development, for anteroposterior patterning; during germline development, the MES-2/MES-3/MES-6 complex is believed to be essential for maintaining repression of the X chromosome, and in transgenic animals, the complex is necessary for germline repression of repetitive transgenes; in axial patterning, the MES-2/MES-3/MES-6 complex is required in somatic tissues for maintaining homeotic gene repression, acting upstream of the Hox genes lin-39, mab-5, and egl-5, as well as the egl-5 target gene lin-32; MES-6 expression is detected in the nuclei of all cells during early embryogenesis, in the germline precursors Z2 and Z3 and faintly in some somatic cells during late embryogenesis and the L1 larval stage, widely in later larvae, and in germline and oocyte nuclei in adults; normal MES-6 distribution is dependent upon wild-type activity of MES-2 and MES-3, and likewise, distribution of MES-3 is dependent upon wild-type activity of MES-2 and MES-6
KOG Annotation  Transcriptional repressor EED/ESC/FIE, required for transcriptional silencing, WD repeat superfamily
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 171
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.5
External "C09G4.5" Links  Wormbase NCBI
MV_SV:mv_AAC27122 Phenotypes Help with Phenotypes
Phenotype  WTRNAi did not cause viable post-embryonic phenotype
MV_SV:mv_AAC27122 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_AAC27122 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of C09G4.4 Browse using GBrowse
Gene Graph
Gene Plot of C09G4.5 Browse using GBrowse
Gene Graph