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RNAi Experiment: MV_SV:mv_AAC47313 Ace View of MV_SV:mv_AAC47313
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F53G12.5 (mex-3)
Description of "F53G12.5"  mex-3 encodes two KH domain-containing RNA binding proteins; in the early embryo, maternally provided MEX-3 is required for specifying the identities of the anterior AB blastomere and its descendants, as well as for the identity of the P3 blastomere and proper segregation of the germline P granules; mex-3 mRNA is distributed uniformly in the syncytial core of the adult distal gonad, mature oocytes, and early 1-cell stage embryos, but then becomes more prominent in the AB blastomere and its daughters by the 4-cell stage after which it is rapidly degraded save for the D and P4 blastomeres; MEX-3 protein is also detected uniformly in the cytoplasm of oocytes and 1-cell stage embryos, but like the mRNA, becomes more abundant in AB and its daughters at the 2- and 4-cell stages, respectively, before disappearing; MEX-3 is also detected in association with P granules from the 2-cell stage until the late stages of embryogenesis.
KOG Annotation  Predicted RNA binding protein, contains KH domain
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 1119
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F53G12.5" Links  Wormbase NCBI
MV_SV:mv_AAC47313 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
MV_SV:mv_AAC47313 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_AAC47313 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of F53G12.5 Browse using GBrowse
Gene Graph