Link to B0207.4RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
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RNAi Experiment: MV_SV:mv_AAC70945 Ace View of MV_SV:mv_AAC70945
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  B0207.4 (air-2)
Description of "B0207.4"  air-2 encodes an aurora/Ip11-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies.
KOG Annotation  Serine/threonine protein kinase
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 810
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "B0207.4" Links  Wormbase NCBI
MV_SV:mv_AAC70945 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Adult  Pvl penetrance is less than 90%
Phenotype  Unclassified reduced brood size
MV_SV:mv_AAC70945 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_AAC70945 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of B0207.4 Browse using GBrowse
Gene Graph