RNAi Experiment: MV_SV:mv_AAC70945 |
Ace View of MV_SV:mv_AAC70945
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Genes Inhibited |
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Gene Inhibited |
B0207.4 (air-2) |
Description of "B0207.4" |
air-2 encodes an aurora/Ip11-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies. |
KOG Annotation  |
Serine/threonine protein kinase
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Evidence for Inhibition |
Sliding Window |
Raw score: 810
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "B0207.4" Links |
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MV_SV:mv_AAC70945 Phenotypes |
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Embryonic |
Emb Penetrance None reported |
Adult |
Pvl
penetrance is less than 90%
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Phenotype |
Unclassified
reduced brood size
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MV_SV:mv_AAC70945 Experiment Details |
Ace View |
Laboratory |
MV |
RNAi Reagent & Type |
mv_AAC70945 (ORFeome_reagent) |
Remark |
bacterial-feeding RNAi began at the L1 larval stage |
Reference |
Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...." |
Delivery Method |
Bacterial_feeding |
Date |
2004-9-01 |
Gene Plot of B0207.4 |
Browse using GBrowse
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