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RNAi Experiment: MV_SV:mv_AAD05570 Ace View of MV_SV:mv_AAD05570
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C32F10.2 (lin-35)
Description of "C32F10.2"  lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, lin-35 activity is required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells.
KOG Annotation  Rb (Retinoblastoma tumor suppressor)-related protein
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 2673
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C32F10.2" Links  Wormbase NCBI
MV_SV:mv_AAD05570 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Unclassified reduced brood size
MV_SV:mv_AAD05570 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_AAD05570 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of C32F10.2 Browse using GBrowse
Gene Graph