RNAi Experiment: MV_SV:mv_AAD48898 |
Ace View of MV_SV:mv_AAD48898
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Genes Inhibited |
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Gene Inhibited |
F19B2.4 (srz-36) |
Evidence for Inhibition |
Sliding Window |
Raw score: 92
Relative score: 0.084 (Best raw score= for Gene )
Specificity index: 0.061 |
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External "F19B2.4" Links |
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Gene Inhibited |
F18H3.5 (cdk-4) |
Description of "F18H3.5" |
cdk-4 encodes two isoforms of a cyclin-dependent serine/threonine protein kinase orthologous to human CDK4 and CDK6 (OMIM:123829 and OMIM:603368, mutated in cutanous malignant melanoma) which complex with D-type cyclins to regulate progression through the G1 phase of the cell cycle; CDK-4 activity is essential for G1 progression in postembryonic blast cells and as a result, cdk-4 mutant animals generally arrest during larval stages; the lethality generated by cdk mutations, also seen in animals doubly mutant for cdk-4 and cyd-1, a C. elegans D-type cyclin, can be suppressed by mutations in lin-35/Rb suggesting that, as in other organisms, LIN-35/Rb may be a major target of CDK-4/CYD-1 kinase activity; CDK-4 expression is first detected in neuronal and hypodermal lineages during mid-to-late embryogenesis, with postembryonic expression detected in hypodermal seam cells, cells of the P lineage which will give rise to ventral cord neurons, and cells of the somatic gonad, the vulva, and the intestine. |
KOG Annotation  |
Protein kinase PCTAIRE and related kinases
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Evidence for Inhibition |
Sliding Window |
Raw score: 1094
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.726 |
Wormbase (BLAST) |
RNAi primary |
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External "F18H3.5" Links |
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Gene Inhibited |
F41H8.3 (srx-30) |
Evidence for Inhibition |
Sliding Window |
Raw score: 320
Relative score: 0.293 (Best raw score= for Gene )
Specificity index: 0.212 |
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External "F41H8.3" Links |
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MV_SV:mv_AAD48898 Phenotypes |
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Phenotype |
WTRNAi did not cause viable post-embryonic phenotype
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MV_SV:mv_AAD48898 Experiment Details |
Ace View |
Laboratory |
MV |
RNAi Reagent & Type |
mv_AAD48898 (ORFeome_reagent) |
Remark |
bacterial-feeding RNAi began at the L1 larval stage |
Reference |
Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...." |
Delivery Method |
Bacterial_feeding |
Date |
2004-9-01 |
Gene Plot of F19B2.4 |
Browse using GBrowse
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Gene Plot of F18H3.5 |
Browse using GBrowse
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Gene Plot of F41H8.3 |
Browse using GBrowse
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