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RNAi Experiment: MV_SV:mv_B0348.6 Ace View of MV_SV:mv_B0348.6
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  B0348.6 (ife-3)
Description of "B0348.6"  ife-3 encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; by homology, IFE-3 is predicted to bind capped mRNA and mediate its recruitment to ribosomes during translation initiation; in vitro, IFE-3 binds a monomethylated guanosine cap structure but does not bind a trimethylated guanosine cap, which suggests that IFE-3 likely mediates translation of those mRNAs that do not contain a spliced-leader sequence; of the C. elegans eIF4E isoforms, IFE-3 is the most similar to human eIF4E and is the only isoform required for viability (homozygous ife-3 mutant embryos arrest in the early division stages of embryogenesis); IFE-3 is enriched in the adult gonad.
Evidence for Inhibition 
Sliding Window Raw score: 669
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "B0348.6" Links  Wormbase NCBI
MV_SV:mv_B0348.6 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Unclassified reduced brood size
MV_SV:mv_B0348.6 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_B0348.6 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of B0348.6 Browse using GBrowse
Gene Graph