RNAi Experiment: MV_SV:mv_B0464.5c |
Ace View of MV_SV:mv_B0464.5c
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Genes Inhibited |
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Gene Inhibited |
B0464.5 (spk-1) |
Description of "B0464.5" |
spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). |
KOG Annotation  |
Serine/threonine protein kinase
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Evidence for Inhibition |
Sliding Window |
Raw score: 3025
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "B0464.5" Links |
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MV_SV:mv_B0464.5c Phenotypes |
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Larval |
Let
penetrance is less than 90%
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Adult |
Pvl Ste
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MV_SV:mv_B0464.5c Experiment Details |
Ace View |
Laboratory |
MV |
RNAi Reagent & Type |
mv_B0464.5c (ORFeome_reagent) |
Remark |
bacterial-feeding RNAi began at the L1 larval stage |
Reference |
Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...." |
Delivery Method |
Bacterial_feeding |
Date |
2004-9-01 |
Gene Plot of B0464.5 |
Browse using GBrowse
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