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RNAi Experiment: MV_SV:mv_B0464.5c Ace View of MV_SV:mv_B0464.5c
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  B0464.5 (spk-1)
Description of "B0464.5"  spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600).
KOG Annotation  Serine/threonine protein kinase
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 3025
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "B0464.5" Links  Wormbase NCBI
MV_SV:mv_B0464.5c Phenotypes Help with Phenotypes
Larval  Let penetrance is less than 90%
Adult  Pvl
Ste
MV_SV:mv_B0464.5c Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_B0464.5c (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of B0464.5 Browse using GBrowse
Gene Graph