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RNAi Experiment: MV_SV:mv_BAA07542 Ace View of MV_SV:mv_BAA07542
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  Y105E8B.1 (lev-11)
Description of "Y105E8B.1"  lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line.
Evidence for Inhibition 
Sliding Window Raw score: 312
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "Y105E8B.1" Links  Wormbase NCBI
MV_SV:mv_BAA07542 Phenotypes Help with Phenotypes
Larval  Let penetrance is less than 90%
Adult  Bmd
Lon
Sck
Ste
MV_SV:mv_BAA07542 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_BAA07542 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of Y105E8B.1 Browse using GBrowse
Gene Graph