Ace View of MV_SV:mv_BAA07542 | ||||||
Gene Inhibited | Y105E8B.1 (lev-11) | |||||
Description of "Y105E8B.1" | lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line. | |||||
Evidence for Inhibition |
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External "Y105E8B.1" Links | ||||||
Larval | Let
penetrance is less than 90% |
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Adult | Bmd Lon Sck Ste |
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Laboratory | MV | |||||
RNAi Reagent & Type | mv_BAA07542 (ORFeome_reagent) | |||||
Remark | bacterial-feeding RNAi began at the L1 larval stage | |||||
Reference | Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...." | |||||
Delivery Method | Bacterial_feeding | |||||
Date | 2004-9-01 | |||||
Gene Plot of Y105E8B.1 | ||||||