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RNAi Experiment: MV_SV:mv_C02F5.1 Ace View of MV_SV:mv_C02F5.1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C02F5.1 (knl-1)
Description of "C02F5.1"  knl-1 encodes a novel acidic protein with a coiled-coil region at its C-terminus; KNL-1 is an essential kinetochore component that is required for proper spindle elongation and chromosome separation, and in the kinetochore assembly pathway, plays a key role in linking the initiation of kinetochore formation with the construction of a functional microtubule-binding interface; in the assembly pathway, KNL-1 functions downstream of the DNA-proximal kinetochore components CeCENP-A/HCP-3 and CeCENP-B/HCP-4 and upstream of the outer kinetochore components HIM-10/Nuf2p, NDC-80/HEC1, CeBUB-1, HCP-1, and CeCLASP2/CLS-2; in expression studies in the one-cell embryo, KNL-1 localizes to kinetochores throughout mitosis.
Evidence for Inhibition 
Sliding Window Raw score: 2883
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C02F5.1" Links  Wormbase NCBI
MV_SV:mv_C02F5.1 Phenotypes Help with Phenotypes
Adult  Pvl
Ste
MV_SV:mv_C02F5.1 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_C02F5.1 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of C02F5.1 Browse using GBrowse
Gene Graph