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RNAi Experiment: MV_SV:mv_C05D11.6 Ace View of MV_SV:mv_C05D11.6
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C05D11.6 (nas-4)
Description of "C05D11.6"  nas-4 encodes a predicted extracellular matrix metalloprotease of the M12A (astacin) family that contains an N-terminal signal sequence and a catalytic domain, but no recognizable regulatory domains in the C-terminus; as loss of nas-4 activity via RNAi results in no obvious abnormalities, the precise role of NAS-4 in C. elegans development and/or behavior is not yet known; however, an NAS-4 translational reporter is expressed in the pharynx and intestine in larvae and adults, suggesting a role for NAS-4 in digestion; NAS-4 is specifically detected within cells of the pharyngeal procorpus, metacorpus, isthmus, and terminal bulb, with extracellular expression detected in the lumen of the terminal bulb and in the gut.
KOG Annotation  Meprin A metalloprotease
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 736
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C05D11.6" Links  Wormbase NCBI
MV_SV:mv_C05D11.6 Phenotypes Help with Phenotypes
Phenotype  WTRNAi did not cause viable post-embryonic phenotype
MV_SV:mv_C05D11.6 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_C05D11.6 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of C05D11.6 Browse using GBrowse
Gene Graph