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RNAi Experiment: MV_SV:mv_C08B6.9 Ace View of MV_SV:mv_C08B6.9
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C08B6.9 (aos-1)
Description of "C08B6.9"  aos-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Aos1p and human SUMO-1 activating enzyme E1 N subunit; by homology, AOS-1 is predicted to form, with a catalytic subunit, UBA-2, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, AOS-1 is required for embryonic and larval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation.
KOG Annotation  SMT3/SUMO-activating complex, AOS1/RAD31 component
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 924
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C08B6.9" Links  Wormbase NCBI
MV_SV:mv_C08B6.9 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Adult  Ooc
Phenotype  Unclassified reduced brood size
MV_SV:mv_C08B6.9 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_C08B6.9 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of C08B6.9 Browse using GBrowse
Gene Graph