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RNAi Experiment: MV_SV:mv_C14A4.4 Ace View of MV_SV:mv_C14A4.4
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C14A4.4 (crn-3)
Description of "C14A4.4"  crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial.
Evidence for Inhibition 
Sliding Window Raw score: 2523
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C14A4.4" Links  Wormbase NCBI
MV_SV:mv_C14A4.4 Phenotypes Help with Phenotypes
Phenotype  WTRNAi did not cause viable post-embryonic phenotype
MV_SV:mv_C14A4.4 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_C14A4.4 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of C14A4.4 Browse using GBrowse
Gene Graph