| RNAi Experiment: MV_SV:mv_D2045.6 |
Ace View of MV_SV:mv_D2045.6
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| Genes Inhibited |
 |
| Gene Inhibited |
D2045.6 (cul-1) |
| Description of "D2045.6" |
cul-1 encodes a cullin, orthologous to Cdc53/Cul1 in S. cerevisiae and CUL-1 in humans (OMIM:603134), that is required both maternally and zygotically for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway, and that is probably also required for normally slow G1-to-S phase progression; CUL-1 physically interacts with eight Skp1-related proteins (SKR-1, -2, -3, -4, -7, -8, -9, and -10). |
| KOG Annotation |
Cullins
|
|
| Evidence for Inhibition |
| Sliding Window |
Raw score: 2190
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
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| External "D2045.6" Links |
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| MV_SV:mv_D2045.6 Phenotypes |
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|
| Embryonic |
Emb Penetrance None reported |
| Larval |
Lva
phenotype observed among F1 progeny of treated animals
|
| Phenotype |
Unclassified
reduced brood size
|
| MV_SV:mv_D2045.6 Experiment Details |
Ace View |
| Laboratory |
MV |
| RNAi Reagent & Type |
mv_D2045.6 (ORFeome_reagent) |
| Remark |
bacterial-feeding RNAi began at the L1 larval stage |
| Reference |
Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...." |
| Delivery Method |
Bacterial_feeding |
| Date |
2004-9-01 |
| Gene Plot of D2045.6 |
Browse using GBrowse
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