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RNAi Experiment: MV_SV:mv_F10B5.6 Ace View of MV_SV:mv_F10B5.6
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F10B5.6 (emb-27)
Description of "F10B5.6"  emb-27 encodes a tetratricopeptide repeat (TPR)-containing protein that is the C. elegans ortholog of the anaphase-promoting complex (APC) subunit APC-6 (CDC16); required maternally and paternally, EMB-27 activity is essential for proper execution of the metaphase-to-anaphase transition during meiosis (both oogenesis and spermatogenesis) and mitosis (during germline proliferation); EMB-27 activity is also critical for embryonic anterior-posterior (A-P) axis formation, production of the secreted eggshell, and normal vulval development; in establishing the embryonic A-P axis, EMB-27 likely acts upstream of the separin protease to ensure proper localization of PAR-3 and PAR-2 to the anterior and posterior cortices, respectively.
KOG Annotation  Anaphase-promoting complex (APC), Cdc16 subunit
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 1818
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F10B5.6" Links  Wormbase NCBI
MV_SV:mv_F10B5.6 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Adult  Stp
MV_SV:mv_F10B5.6 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_F10B5.6 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of F10B5.6 Browse using GBrowse
Gene Graph