Link to C37H5.8RNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 
RNAi Experiment: MV_SV:mv_G_YK200 Ace View of MV_SV:mv_G_YK200
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C37H5.8 (hsp-6)
Description of "C37H5.8"  hsp-6 encodes a mitochondrial-specific chaperone that is a member of the DnaK/Hsp70 superfamily of molecular chaperones; hsp-6 is believed to be involved in the mitochondrial unfolded protein response, as hsp-6 expression, normally broadly detected from the L1 larval through adult stages of development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-6 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development.
KOG Annotation  Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 1887
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C37H5.8" Links  Wormbase NCBI
MV_SV:mv_G_YK200 Phenotypes Help with Phenotypes
Larval  Lva
MV_SV:mv_G_YK200 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_G_YK200 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of C37H5.8 Browse using GBrowse
Gene Graph