| RNAi Experiment: MV_SV:mv_G_YK365_1 |
Ace View of MV_SV:mv_G_YK365_1
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| Genes Inhibited |
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| Gene Inhibited |
C36E8.5 (tbb-2) |
| Description of "C36E8.5" |
tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis. |
| KOG Annotation |
Beta tubulin
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| Evidence for Inhibition |
| Sliding Window |
Raw score: 1224
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
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| External "C36E8.5" Links |
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| MV_SV:mv_G_YK365_1 Phenotypes |
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| Larval |
Lvl
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| MV_SV:mv_G_YK365_1 Experiment Details |
Ace View |
| Laboratory |
MV |
| RNAi Reagent & Type |
mv_G_YK365_1 (ORFeome_reagent) |
| Remark |
bacterial-feeding RNAi began at the L1 larval stage |
| Reference |
Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...." |
| Delivery Method |
Bacterial_feeding |
| Date |
2004-9-01 |
| Gene Plot of C36E8.5 |
Browse using GBrowse
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