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RNAi Experiment: MV_SV:mv_G_YK5313 Ace View of MV_SV:mv_G_YK5313
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  B0464.7 (baf-1)
Description of "B0464.7"  baf-1 encodes a small, novel protein that is highly conserved amongst metazoa; BAF-1 binds double-stranded DNA nonspecifically in vitro and is essential for proper chromosome segregation, embryogenesis, and gonad development in vivo; biochemical and phenotypic analyses suggest that BAF-1 functions as an intramolecular bridge that mediates nuclear assembly and chromatin capture by the reforming nuclear envelope; by homology with mammalian BAF proteins, BAF-1 is also predicted to play a role in regulating gene expression and higher-order chromatin structure; during interphase, BAF-1 colocalizes with LMN-1/lamin to the nuclear envelope and nuclear interior; during mitosis, BAF-1 is present in a more punctate pattern, localizing near condensing chromatin and maintaining this localization through telophase; BAF-1 localization during nuclear assembly requires the activity of LMN-1/lamin, EMR-1/emerin, and LEM-2/MAN1.
KOG Annotation  DNA-bridging protein BAF
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 330
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "B0464.7" Links  Wormbase NCBI
MV_SV:mv_G_YK5313 Phenotypes Help with Phenotypes
Adult  Bmd phenotype observed among F1 progeny of treated animals
Unc
Phenotype  Unclassified reduced brood size
MV_SV:mv_G_YK5313 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_G_YK5313 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of B0464.7 Browse using GBrowse
Gene Graph