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RNAi Experiment: MV_SV:mv_K04G2.8b Ace View of MV_SV:mv_K04G2.8b
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  K04G2.8 (apr-1)
Description of "K04G2.8"  The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39.
KOG Annotation  Beta-catenin-binding protein APC, contains ARM repeats
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 3417
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "K04G2.8" Links  Wormbase NCBI
MV_SV:mv_K04G2.8b Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Larval  Lva phenotype observed among F1 progeny of treated animals
MV_SV:mv_K04G2.8b Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_K04G2.8b (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of K04G2.8 Browse using GBrowse
Gene Graph