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RNAi Experiment: MV_SV:mv_R06F6.1 Ace View of MV_SV:mv_R06F6.1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  R06F6.1 (cdl-1)
Description of "R06F6.1"  cdl-1 encodes a homolog of human hairpin (stem-loop) binding proteins (HBP/SLBP) that bind to the hairpin (stem-loop) structure in the 3' untranslated region (3' UTR) of histone mRNAs, and thus promote histone pre-mRNA processing and translation of mature histone mRNA; CDL-1 is required for normally high levels of histone gene expression, normal cell division during late larval development, embryonic viability, normal vulval morphogenesis, normally rapid apoptosis, and fertility; CDL-1 binds to the stem-loop structure in the 3' UTR of core-histone mRNA; the cdl-1 promoter is most active in dividing cells during embryogenesis and postembryonic development; both CDL-1 and human HBP contain a minimal RNA-binding domain (RBD) of roughly 73 amino acids that has no similarity with other known RNA-binding motifs.
KOG Annotation  Histone mRNA stem-loop binding protein
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 996
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "R06F6.1" Links  Wormbase NCBI
MV_SV:mv_R06F6.1 Phenotypes Help with Phenotypes
Adult  Pvl
Ste
MV_SV:mv_R06F6.1 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_R06F6.1 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of R06F6.1 Browse using GBrowse
Gene Graph