RNAi Experiment: MV_SV:mv_R06F6.1 |
Ace View of MV_SV:mv_R06F6.1
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Genes Inhibited |
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Gene Inhibited |
R06F6.1 (cdl-1) |
Description of "R06F6.1" |
cdl-1 encodes a homolog of human hairpin (stem-loop) binding proteins (HBP/SLBP) that bind to the hairpin (stem-loop) structure in the 3' untranslated region (3' UTR) of histone mRNAs, and thus promote histone pre-mRNA processing and translation of mature histone mRNA; CDL-1 is required for normally high levels of histone gene expression, normal cell division during late larval development, embryonic viability, normal vulval morphogenesis, normally rapid apoptosis, and fertility; CDL-1 binds to the stem-loop structure in the 3' UTR of core-histone mRNA; the cdl-1 promoter is most active in dividing cells during embryogenesis and postembryonic development; both CDL-1 and human HBP contain a minimal RNA-binding domain (RBD) of roughly 73 amino acids that has no similarity with other known RNA-binding motifs. |
KOG Annotation  |
Histone mRNA stem-loop binding protein
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Evidence for Inhibition |
Sliding Window |
Raw score: 996
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "R06F6.1" Links |
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MV_SV:mv_R06F6.1 Phenotypes |
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Adult |
Pvl Ste
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MV_SV:mv_R06F6.1 Experiment Details |
Ace View |
Laboratory |
MV |
RNAi Reagent & Type |
mv_R06F6.1 (ORFeome_reagent) |
Remark |
bacterial-feeding RNAi began at the L1 larval stage |
Reference |
Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...." |
Delivery Method |
Bacterial_feeding |
Date |
2004-9-01 |
Gene Plot of R06F6.1 |
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