| RNAi Experiment: MV_SV:mv_R10E11.1 |
Ace View of MV_SV:mv_R10E11.1
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| Genes Inhibited |
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| Gene Inhibited |
R10E11.1 (cbp-1) |
| Description of "R10E11.1" |
cbp-1 encodes a homolog of the mammalian transcriptional cofactors CBP (OMIM:600140) and p300 (E1A-BINDING PROTEIN, 300-KD; OMIM:602700) that have been shown to possess histone acetyltransferase activity, and which, when mutated, lead to Rubinstein-Taybi syndrome (OMIM:180849) and colorectal cancer (OMIM:114500); at least one splicing form of CBP-1 exhibits histone acetyltransferase (HAT) activity in vitro and has a glutamine/asparagine-rich domain; CBP-1 is required during embryogenesis for differentiation of all non-neuronal somatic cell types; CBP-1 is expressed very early in embryogenesis, suggesting that it may interact with maternally provided transcription factors, such as SKN-1, to specific developmental fates. |
| KOG Annotation |
CREB binding protein/P300 and related TAZ Zn-finger proteins
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| Evidence for Inhibition |
| Sliding Window |
Raw score: 5853
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
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| External "R10E11.1" Links |
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| MV_SV:mv_R10E11.1 Phenotypes |
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| Phenotype |
WTRNAi did not cause viable post-embryonic phenotype
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| MV_SV:mv_R10E11.1 Experiment Details |
Ace View |
| Laboratory |
MV |
| RNAi Reagent & Type |
mv_R10E11.1 (ORFeome_reagent) |
| Remark |
bacterial-feeding RNAi began at the L1 larval stage |
| Reference |
Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...." |
| Delivery Method |
Bacterial_feeding |
| Date |
2004-9-01 |
| Gene Plot of R10E11.1 |
Browse using GBrowse
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