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RNAi Experiment: MV_SV:mv_T05C12.6a Ace View of MV_SV:mv_T05C12.6a
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  T05C12.6 (mig-5)
Description of "T05C12.6"  mig-5 encodes one of three C. elegans Dishevelled homologs; as part of both canonical and non-canonical Wnt signaling pathways, mig-5 activity is required maternally and embryonically for cell migration, cell fate specification, and proper spindle orientation in the early embryo; cells affected by mig-5 mutations include the distal tip cells (DTCs), the QL neuroblast descendants (QL.d), the vulval precursor cells, and the P12 ectoblast; in the early embryo, MIG-5 functions downstream of MOM-2/Wnt and MOM-1/Porc, and redundantly with two other Dishevelled homologs, DSH-1 and DSH-2, in a non-canonical Wnt pathway that specifies the endoderm cell fate and regulates mitotic spindle orientation in the EMS and ABar blastomeres; in posteriorly directed QL.d migrations, MIG-5 functions downstream of EGL-20/Wnt and upstream of PRY-1/Axin in a canonical Wnt pathway to positively regulate Wnt signaling and effect MAB-5 expression in QL.d; a mig-5::GFP fusion is reportedly expressed in many cells in the embryo, migrating DTCs, P cells, and the nerve ring.
KOG Annotation  Dishevelled 3 and related proteins
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 1840
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "T05C12.6" Links  Wormbase NCBI
MV_SV:mv_T05C12.6a Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
MV_SV:mv_T05C12.6a Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_T05C12.6a (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of T05C12.6 Browse using GBrowse
Gene Graph