RNAi Experiment: MV_SV:mv_T05C12.6a |
Ace View of MV_SV:mv_T05C12.6a
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Genes Inhibited |
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Gene Inhibited |
T05C12.6 (mig-5) |
Description of "T05C12.6" |
mig-5 encodes one of three C. elegans Dishevelled homologs; as part of both canonical and non-canonical Wnt signaling pathways, mig-5 activity is required maternally and embryonically for cell migration, cell fate specification, and proper spindle orientation in the early embryo; cells affected by mig-5 mutations include the distal tip cells (DTCs), the QL neuroblast descendants (QL.d), the vulval precursor cells, and the P12 ectoblast; in the early embryo, MIG-5 functions downstream of MOM-2/Wnt and MOM-1/Porc, and redundantly with two other Dishevelled homologs, DSH-1 and DSH-2, in a non-canonical Wnt pathway that specifies the endoderm cell fate and regulates mitotic spindle orientation in the EMS and ABar blastomeres; in posteriorly directed QL.d migrations, MIG-5 functions downstream of EGL-20/Wnt and upstream of PRY-1/Axin in a canonical Wnt pathway to positively regulate Wnt signaling and effect MAB-5 expression in QL.d; a mig-5::GFP fusion is reportedly expressed in many cells in the embryo, migrating DTCs, P cells, and the nerve ring. |
KOG Annotation  |
Dishevelled 3 and related proteins
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Evidence for Inhibition |
Sliding Window |
Raw score: 1840
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "T05C12.6" Links |
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MV_SV:mv_T05C12.6a Phenotypes |
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Embryonic |
Emb Penetrance None reported |
MV_SV:mv_T05C12.6a Experiment Details |
Ace View |
Laboratory |
MV |
RNAi Reagent & Type |
mv_T05C12.6a (ORFeome_reagent) |
Remark |
bacterial-feeding RNAi began at the L1 larval stage |
Reference |
Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...." |
Delivery Method |
Bacterial_feeding |
Date |
2004-9-01 |
Gene Plot of T05C12.6 |
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