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RNAi Experiment: MV_SV:mv_T22C8.8 Ace View of MV_SV:mv_T22C8.8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  T22C8.8 (vab-9)
Description of "T22C8.8"  vab-9 encodes a claudin homolog orthologous to human brain cell membrane protein 1 (BCMP1) and Drosophila CG6982; VAB-9 colocalizes with HMP-1 to an apical layer of the adherens junctions of all epithelial cells, one layer more apically than AJM-1; vab-9 mutants have disorganized F-actin at the adherens junction, implying that VAB-9 links junctions to circumferential actin filaments; VAB-9 is also expressed in the nerve ring; VAB-9 requires the cadherin HMR-1 to localize to the cell membrane, and both alpha-catenin (HMP-1) and beta-catenin (HMP-2) to remain at the cell junction after membrane localization.
KOG Annotation  Brain cell membrane protein 1 (BCMP1)
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 549
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "T22C8.8" Links  Wormbase NCBI
MV_SV:mv_T22C8.8 Phenotypes Help with Phenotypes
Phenotype  WTRNAi did not cause viable post-embryonic phenotype
MV_SV:mv_T22C8.8 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_T22C8.8 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of T22C8.8 Browse using GBrowse
Gene Graph