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RNAi Experiment: MV_SV:mv_VF13D12L.2 Ace View of MV_SV:mv_VF13D12L.2
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C47D12.8
Description of "C47D12.8"  C47D12.8 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to xeroderma pigmentosum (complementation group F; OMIM:133520); C47D12.8(RNAi) animals are hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; C47D12.8 protein interacts with F10G8.7 (an ERCC1 ortholog) in yeast two-hybrid assays; C47D12.8 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; C47D12.8 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3.
KOG Annotation  Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 1014
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C47D12.8" Links  Wormbase NCBI
MV_SV:mv_VF13D12L.2 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
MV_SV:mv_VF13D12L.2 Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_VF13D12L.2 (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of C47D12.8 Browse using GBrowse
Gene Graph