RNAi Experiment: MV_SV:mv_VF13D12L.2 |
Ace View of MV_SV:mv_VF13D12L.2
|
Genes Inhibited |
|
Gene Inhibited |
C47D12.8 |
Description of "C47D12.8" |
C47D12.8 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to xeroderma pigmentosum (complementation group F; OMIM:133520); C47D12.8(RNAi) animals are hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; C47D12.8 protein interacts with F10G8.7 (an ERCC1 ortholog) in yeast two-hybrid assays; C47D12.8 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; C47D12.8 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3. |
KOG Annotation  |
Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4
|
|
Evidence for Inhibition |
Sliding Window |
Raw score: 1014
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
|
External "C47D12.8" Links |
|
MV_SV:mv_VF13D12L.2 Phenotypes |
|
|
Embryonic |
Emb Penetrance None reported |
MV_SV:mv_VF13D12L.2 Experiment Details |
Ace View |
Laboratory |
MV |
RNAi Reagent & Type |
mv_VF13D12L.2 (ORFeome_reagent) |
Remark |
bacterial-feeding RNAi began at the L1 larval stage |
Reference |
Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...." |
Delivery Method |
Bacterial_feeding |
Date |
2004-9-01 |
Gene Plot of C47D12.8 |
Browse using GBrowse
|
|