Link to W02A11.4RNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
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RNAi Experiment: MV_SV:mv_W02A11.4a Ace View of MV_SV:mv_W02A11.4a
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  W02A11.4 (uba-2)
Description of "W02A11.4"  uba-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Uba2p and human ubiquitin-like 2 activating enzyme E1B; by homology, UBA-2 is predicted to form, with a regulatory subunit, AOS-1, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, UBA-2 is required for embryogenesis and vulval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation.
KOG Annotation  SMT3/SUMO-activating complex, catalytic component UBA2
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 1128
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "W02A11.4" Links  Wormbase NCBI
MV_SV:mv_W02A11.4a Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Larval  Gro phenotype observed among F1 progeny of treated animals
Lva penetrance is less than 90%
MV_SV:mv_W02A11.4a Experiment Details Ace View
Laboratory  MV
RNAi Reagent & Type  mv_W02A11.4a (ORFeome_reagent)
Remark  bacterial-feeding RNAi began at the L1 larval stage
Reference  Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...."
Delivery Method  Bacterial_feeding
Date  2004-9-01
Gene Plot of W02A11.4 Browse using GBrowse
Gene Graph